World health leaders have described superbugs as “nightmare bacteria” that “pose a catastrophic threat” to people in every country in the world. Understanding how superbugs develop, what their resistance mechanisms are, and the impact they have on human health is key to combatting the threat.
Superbugs evolve in a few ways. When bacteria grow and spread, they can develop mutations in their DNA that make them resistant to certain types of drugs. When antibiotics are used to treat an infection, bacteria without the resistance mechanism die, while those that have the resistance mechanism may continue to live and multiply. Bacteria can also give certain resistance mechanisms to other bacteria in a process called horizontal gene transfer, which increases the speed at which bacteria can evolve into superbugs.
To learn more about individual superbug species,
download the bad bugs flash cards.
Superbugs’ resistance mechanisms take a variety of forms. Some act like camouflage, hiding the bacterium’s vulnerable cell wall from the antibiotic, while others act like shields against antibiotics. One of the most pernicious resistance mechanisms is a biological pump that actively flushes an antibiotic compound out of the bacterium. Some bacteria have enzymes that can degrade antibiotics before they do any damage. As these resistance mechanisms continue to change and spread among superbugs, antibiotics can become ineffective, and the threat of antibiotic resistance becomes more urgent than ever. The impact on human health is clear:
When first-line and then second-line antibiotic treatment options are limited by resistance or are unavailable, healthcare providers are forced to use antibiotics that may be more toxic to the patient and frequently more expensive. Even when alternative treatments exist, research has shown that patients with resistant infections are often much more likely to die, and survivors have significantly longer hospital stays, delayed recuperation, and long-term disability.
Efforts to prevent such threats build on the foundation of proven public health strategies: immunization, infection control, protecting the food supply, antibiotic stewardship, and reducing person-to-person spread through screening, treatment and education.
CDC AR Threat Report: http://www.cdc.gov/drugresistance/pdf/ar-threats-2013-508.pdf